As. Pac. J. Mol. Biol. & Biotech., Dec 2001 Vol. 9(1) : 38-44
Some nitrogen sulfur compounds: Bondings and biological properties
M.T.H. Tarafder 11* N. Saravanan1, A.M. Ali2, A. Kasbollah1, K.A. Crouse1 and K.Y. Yih
1Department of Chemistry, 2Department of Biotechnology, Universiti Putra
Malaysia, 43400 Serdang,
Selangor Malaysia.
(Received 2 October 2001 / Accepted 26 February 2001)
Abstract:
Eleven Schiff bases with different functionalities were prepared from the condensation of S benzyldithiocarbazate (SBDTC) with aldehydes and ketones. Six of these bases had been prepared previously but had not been tested for biological activity. They were chosen because of the variation in biological activity that might be afforded by the different substituent groups. These were all straight chain compounds. The condensation products of 2,3 butanedione were also straight chain derivatives, however, the interactions between acetylacetone, benzoyl chloride and ethyl benzoyl acetate yielded cyclic aromatic compounds. All of the compounds were characterized using elemental analyses and other physico chemical techniques. SBDTC and its Schiff bases were screened for antimicrobial and cytotoxic activities. Although only the S benzyldithiocarbazate showed antimicrobial activity, both it and some of its Schiff bases were cytotoxic to varying degrees.
Key Words: Nitrogen sulphur compounds, cyclization of Schiff bases,
antimicrobial activity, cytotoxicity